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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Identifying hotspots for antibiotic resistance emergence and selection, and elucidating pathways to human exposure: Application of a systems-thinking approach to aquaculture systems
Author(s): Brunton, Lucy A
Desbois, Andrew P
Garza, Maria
Wieland, Barbara
Mohan, Chadag Vishnumurthy
Häsler, Barbara
Tam, Clarence C
Le, Phuc Nguyen Thien
Phuong, Nguyen Thanh
Van, Phan Thi
Nguyen-Viet, Hung
Eltholth, Mahmoud M
Pham, Dang Kim
Duc, Phuc Pham
Adams, Alexandra
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Keywords: Antimicrobial resistance (AMR)
Cá Tra
Mekong Delta
One Health
Pangasianodon hypophthalmus
Penaeus vannamei
Issue Date: 15-Oct-2019
Date Deposited: 2-Jul-2019
Citation: Brunton LA, Desbois AP, Garza M, Wieland B, Mohan CV, Häsler B, Tam CC, Le PNT, Phuong NT, Van PT, Nguyen-Viet H, Eltholth MM, Pham DK, Duc PP & Adams A (2019) Identifying hotspots for antibiotic resistance emergence and selection, and elucidating pathways to human exposure: Application of a systems-thinking approach to aquaculture systems. Science of The Total Environment, 687, pp. 1344-1356.
Abstract: Aquaculture systems are highly complex, dynamic and interconnected systems influenced by environmental, biological, cultural, socio-economic and human behavioural factors. Intensification of aquaculture production is likely to drive indiscriminate use of antibiotics to treat or prevent disease and increase productivity, often to compensate for management and husbandry deficiencies. Surveillance or monitoring of antibiotic usage (ABU) and antibiotic resistance (ABR) is often lacking or absent. Consequently, there are knowledge gaps for the risk of ABR emergence and human exposure to ABR in these systems and the wider environment. The aim of this study was to use a systems-thinking approach to map two aquaculture systems in Vietnam – striped catfish and white-leg shrimp – to identify hotspots for emergence and selection of resistance, and human exposure to antibiotics and antibiotic-resistant bacteria. System mapping was conducted by stakeholders at an interdisciplinary workshop in Hanoi, Vietnam during January 2018, and the maps generated were refined until consensus. Thereafter, literature was reviewed to complement and cross-reference information and to validate the final maps. The maps and component interactions with the environment revealed the grow-out phase, where juveniles are cultured to harvest size, to be a key hotspot for emergence of ABR in both systems due to direct and indirect ABU, exposure to water contaminated with antibiotics and antibiotic-resistant bacteria, and duration of this stage. The pathways for human exposure to antibiotics and ABR were characterised as: occupational (on-farm and at different handling points along the value chain), through consumption (bacterial contamination and residues) and by environmental routes. By using systems thinking and mapping by stakeholders to identify hotspots we demonstrate the applicability of an integrated, interdisciplinary approach to characterising ABU in aquaculture. This work provides a foundation to quantify risks at different points, understand interactions between components, and identify stakeholders who can lead and implement change.
DOI Link: 10.1016/j.scitotenv.2019.06.134
Rights: This is an open access article distributed under the terms of the Creative Commons CC-BY license (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You are not required to obtain permission to reuse this article.
Notes: Additional co-authors: Nguyen Tuong Linh, Karl M Rich, Ana L P Mateus, Md Ahasanul Hoque, Abdul Ahad, Mohammed Nurul Absar Khan, Javier Guitian
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